![]() Allergic reactions to profilin are intensified when exposed to airborne allergens like grass pollen. 16 Studies have also shown that there is a connection between allergens in food and those in the air. Citrus allergy has been reported to orange, mandarin, and grapefruit, but contrary to the name of the allergy, it’s not caused by citric acid.Ĭitrus allergy is caused by immune responses to lipid transfer proteins known as profilin and pectin. ![]() In severe cases, an allergic reaction could cause anaphylaxis, a potentially life‑threatening reaction that requires immediate medical attention. If you are allergic to a particular citrus fruit, it’s highly likely that others too can trigger an allergic reaction. Grapefruit belongs to the family of citrus fruits which also include limes, lemons, and oranges. If you’re taking drugs that fall under any of the above categories, talk to your doctor about alternatives. Also, you might not have to give up grapefruit just yet as it does not react with all the drugs in a given category. Since grapefruit interferes with the metabolic process of drug absorption, its side effects are usually limited to drugs taken orally. While grapefruit makes other drugs more potent, in the case of fexofenadine, it decreases the absorption making the drug less effective.
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